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Film-coated tablets. The main substance quetiapine (as fumarate) 25, 100 and 200 mg. Other ingredients: povidone, dibasic calcium phosphate dihydrate, MCC; starch (sodium glycolate), lactose monohydrate, magnesium stearate. The composition of the shell: iron oxide red (tablets of 25 mg), iron oxide yellow (tablets of 25 and 100 mg), titanium dioxide, hydroxypropyl methylcellulose, polyethylene glycol 400. In a blister pack of 10.; A stack of cardboard 3 or 6 blisters (tablet 25 mg) or a stack of cardboard 3, 6 or 9 blisters (tablets 100 and 200 mg) or a stack of cardboard 1 blister (6 tablets of 25 mg, 3 tablets of 100 mg and 1 tablet of 200 mg).

Inside, regardless of the meal, 2 times per day. In adults, the daily dose during the first 4 days of therapy is as follows: the first day - 50 mg, second day - 100 mg, the third day - 200 mg, Day 4 - 300 mg. Starting from 4 days the dose should be titrated to the usual effective dosage range from 300 to 450 mg / day. Depending on the clinical effect and tolerability of an individual patient, the dose can vary from 150 to 750 mg / day. Like other antipsychotics, Seroquel should be used with caution in the elderly, especially in the initial period of therapy. In elderly patients the initial dose of Seroquel should be 25 mg per day. The dose should be increased daily by 25-50 mg to achieve an effective dose, which is likely to be lower than in younger patients.
Safety and efficacy of Seroquel in children and adolescents has not been investigated. Patients with impaired liver function and kidney by Seroquel therapy should begin with a dose of 25 mg / day. The dose should be increased daily by 25-50 mg to achieve an effective dose.

With the cardiovascular system and blood (hematopoiesis, hemostasis): Orthostatic hypotension, hypertension, tachycardia, leucopenia. The nervous system and sensory organs: drowsiness, dizziness, anxiety, and rarely - neuroleptic malignant syndrome. From a metabolism: an increase in cholesterol, serum triglycerides, ALT and AST, the change in liver enzymes. From the digestive tract: dry mouth, diarrhea or constipation, indigestion. For the skin: rash, dry skin.
Other: pain syndrome (abdominal pain, headache, backache, muscle aches, chest, ear), asthenia, rhinitis, urinary tract infection, fever, weight gain.

Symptoms: drowsiness, sedation, tachycardia, hypotension.
Treatment: symptomatic, restoration and control of upper airway patency, maintenance of adequate oxygenation and ventilation, monitoring and maintenance of the cardiovascular system.